Behaviour against β-lactams in Aeromonas spp. isolated from extraintestinal infections
نویسندگان
چکیده
The role of Aeromonas spp. in a variety of human illnesses has been well documented during the last decades. The spectrum of infectious diseases caused by Aeromonas species includes gastrointestinal and extraintestinal infections. Aeromonas gastrointestinal infections are generally self-limiting and antibiotic therapy is unnecessary. However, for gastrointestinal infections in immunocompromised patients and extraintestinal infections, it is necessary to implement an appropriate antibiotic treatment. Since the early 1990’s, an increase in antimicrobial resistance of Aeromonas spp. has been observed worldwide. ß-lactam antibiotics are currently the most commonly used antibiotics in developing areas because of their cost, safety and selectivity in the treatment of infections caused by bacterial pathogens. Our results support the hypotheses that it is possible that the therapeutic failures of ß-lactams in the treatment of infections caused by Aeromonas spp. could be associated with the inoculum effect, the expression of inducible ß-lactamases and the emergence of derepressed mutants in vivo.
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